Macclesfield F.C. is a successor to Macclesfield Town. Founded in 1874, Macclesfield Town was liquidated and expelled from the National League in 2020 due to debts of over £500,000. Its assets were put up for sale, including the Moss Rose stadium on the Rightmove property website. In October 2020, the stadium and all available assets were purchased by Robert Smethurst, the owner of Stockport Town, with the aim of returning professional football to Macclesfield by creating the phoenix club as Macclesfield F.C. Smethurst also appointed the Welsh former professional footballer Robbie Savage as a member of the board for the new phoenix club with Danny Whitaker as manager. He also invested in upgrading the stadium to improve the commercial viability of the new club.
In May 2021, it was announced that Macclesfield would be placed in the North West Counties Premier Division for their first season. Savage announced that the club would be joining with his foundation to offer free tickets to foundation participants to encourage youth attendance at the club's matches.